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Club Name : MultipleSclerosis
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Multiple Sclerosis is a chronic disease of the central nervous system, or CNS, which is comprised of the brain and spinal cord. The CNS sends and receives signals through a network of nerves insulated by a protective protein coating called myelin. In MS, myelin is broken down, causing a disruption in these signals. Demyelination is a hallmark of this disease, a process researchers believe may begin before symptoms appear. This furthers the case for early intervention upon diagnosis of relapsing-remitting multiple sclerosis. Mild symptoms often include vision or dexterity problems, numbness or tingling sensations. In some patients, more severe symptoms may eventually include a partial or complete loss of vision or mobility.
In relapsing-remitting multiple sclerosis, the presumed path of MS is as follows:
1. Normally functioning nerves are insulated by a protective protein coating called myelin.
2. In multiple sclerosis, myelin is broken down, causing disruptions in the signals sent to and from the brain.
3. Natural immune cells, or T cells, are believed to bind with lost myelin proteins and become proinflammatory.
4. These harmful T cells are thought to cross the protective blood-brain barrier into the central nervous system (CNS).
5. Inside the CNS, the T cells bind with myelin proteins and release inflammatory substances (cytokines) believed to contribute to myelin breakdown.
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